Professor Castellani is laureated in Biology and Physics and has a Ph.D. in Physics. Professor Castellani is a Full Professor at Bologna University in Italy in Applied Physics-Biophysics, and he is the Director of the Galvani center for Bioinformatics, Biophysics, and Biocomplexity in Italy. From the year 2000, he holds the position of Associate Professor (Research) at Brown University, Providence, RI USA, researching within the group of Professor Leon N Cooper on machine learning, neural networks, and big data analytics of gene expression. He has co-authored more than 200 publications in international peer-reviewed journals. In total, he has more than 200 printed contributions (8000 citations and h index 42). Professor Castellani has been awarded two international prizes: (Chaos and Complexity prize Blois France 1993, Vice President award Brown University 2003) for innovative research in the field of complex biological systems. He is a referee for several journals such as PNAS, Molecular Bio-system, Physical Review, and Bioinformatics. He is one of the founders of the Italian Society for Systems Biology (SysBioHealth). Recently, he obtained a 3-year project from the Programa ciência sem fronteiras – bolsas no país modalidade pesquisador visitante especial titled: SYSAGEOMICS Systems Biology of Aging and Age-related diseases by integration of Multiscale Experimental and Computational Methods. Professor Castellani has also obtained a special grant from Brown University to collaborate with Brasilian Universities of Belo Horizonte on the measurements of circulating nucleic acids. His current research topics are on Machine Learning, Big Data, and Artificial Intelligence applied to Biomedical data.